The major research focus of our research group is to understand the precise tumor-nerve signaling crosstalk that underlie the initiation and maintenance of chronic pain associated with metastatic bone cancers. We are developing and validating rodent models of chronic ongoing/un-evoked pain behaviors associated with bone-metastasized prostate, breast and melanoma cancers, as well as investigating the precise tumor-nerve signaling mechanisms involving pain-transducing ion channels that underlie such chronic painful conditions. Our group is also studying the mechanisms that underlie peripheral pain sensitization under conditions of tissue injury, inflammation and development of obesity. Our overall goal in pain research is to identify and pre-clinically validate specific targets for the development of novel and efficacious pharmacotherapeutics for chronic pain associated with metastatic bone cancers, inflammation and obesity.
In addition to pain research, our studies are also geared towards the understanding of the role of voltage-gated K⁺ channels and ionic mechanisms underlying cellular survival-death dynamics in multiple neurodegenerative conditions, such as stroke-reperfusion injury and exposure to several HIV-1 regulatory/surface proteins. Our multidisciplinary research approach utilizes state-of-the art technologies ranging from cellular, molecular, biochemical, live-cell ion imaging and electrophysiology to multiple behavioral assessments in rodent models of human diseases, including the utilization of mouse genetics.
Washington University Pain Center
Department of Anesthesiology, 5502 CSRB
Washington University School of Medicine in St. Louis
660 S. Euclid Avenue, St. Louis, MO, 63110
Voice: (314) 362-8244
Lab/PI Office: (314) 362-8229
Fax: (314) 362-8334